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2-甲基THF
2-MeTHF: The Value Proposition Advantages from chemical properties Increased reaction yields Increased solubility of organogrignards Less impurities due to higher solvent stability Advantages from physical properties Advantages from chemical properties Increased reaction yields Less impurities due to better solvent stability Advantages from physical properties THF is water miscible Work-up alternatives for THF reactions: Add a hydrophobic solvent for phase separation Increased solvent volumes Hard to recycle solvent mixtures (separation difficult) Persistent emulsions and rag layers Add saline solution for phase separation Doesn’t work for polar compounds Poor product recovery-second extraction needed End-up with mixtures of solvents MeTHF is the solution to THF’s shortcomings: MeTHF is not miscible with water Clean phase separation with no emulsions rag layers Reduced number of extraction steps Easy to dry (forms azeotrope like toluene) Easy to recycle and reuse * 2-METHYLTETRAHYDROFURAN 2-Methyltetrahydrofuran: Simply Better than Tetrahydrofuran Dr. Bogdan Comanita , Penn Specialty Chemicals, Inc. Introduction Penn Specialty Chemicals Inc. has been a leader in furan chemistry for more than 60 years, MeTHF is a furan derivative made from renewable resources with considerable advantages over THF. MeTHF is a rapidly emerging global solvent market and Penn is spearheading the commercialization of this solvent. MeTHF is not only an innovative product but at the same time it is an innovation enabler for the fine chemicals and pharmaceutical industry. I hope that our presentation will convince you that this is in fact the case. Reduced costs Improved process Greener process Comparable/better safety Purchasing RD/Manufacturing Safety Environmental Agenda MeTHF improves processes MeTHF; safety aspects MeTHF makes greener process MeTHF cuts costs Conclusions; MeTHF simply better than THF QA session MeTHF Improves Processes Improved Process:
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