【传染病学课】流脑英文课件.pptVIP

Epidemic CerebrospinalMeningitis DEFINITION 1. Epidemic cerebrospinal meningitis is acute infectious disease caused by meningococcus. 2.characteristics of ECM are fever, headache, vomiting , petechiae or ecchymosis , and meningeal irritation signs. CSF is purulent . ETIOLOGY 1.Pathogen is Neisseria meningitidis (meningococcus); G- diplococcus. 2.Biological features: 2.1.The organism grow by incubation on blood,chocolate or trypticase soy agar in 5~10%CO2,PH 7.4~7.6; 2.2.The organism is susceptible to dry, heat , chill and disinfectant; ETIOLOGY 2.3. autolysis by autolysin in vitro; 3.The organism can be detected in patient’s nasopharynx, blood, CSF, petechiae in skin; 4.Pathogenic factor: endotoxin. ETIOLOGY 5.Serogroups of meningoccus; 13 serogroups and more than 20 serotypes found in the world; most common serogroups: A B C group Group A is the most common in china. EPIDEMIOLOGY 1.Source of infection: patients and carriers; 2.The routes of transmission : 1) air borne 2) closed contact transmission : 3.Susceptibility of population: universal susceptible stable and persistent immunity EPIDEMIOLOGY 4.Epidemiologic feature: (1). Season: November - May high peak: March - April (2).age: 6 months to 2 years old PATHOGENESIS meningococci extinguished nasopharynx carriers 60 - 70% upper respiratory tract infection 20 -30% meningococcemia period septicemia pyogenic meningitis 1% Fulminant type endotoxin microcirc