我国老年人钙化性瓣膜病的研究现状和展望王士雯课件.pptVIP

Clinical and Basic Research on Redegenerative Valvular Heart Disease and Vascular Calcification Background Retrograde valvular heart disease in the elderly：A common valvular disease in the elderly that caused by calcification of heart valves with age. It is the most common reason of valve replacement and mortality Vascular calcification ： common lesion in the elderly indicator of AS degrees pathological foundation of many Vascular disease Background Mobility of RVHD increases in China along with advanced elderly population Compared with other diseases (CHD,DM, et al), research on RVHD remains largely insufficient Study Contents Follow-up study on RVHD Large scale epidemiologic analysis on RVHD and vascular calcification in the elderly Further investigation on clinical and molecular etiology Statins intervention on RVHD and vascular calcification in the elderly Follow-up Research on Clinical Epidemiology of RVHD A 6-year follow to 95 cases of valvular calcification and 95 cases of normal patients Occurrence of murmur,ventricular enlargement,nodal lesion,A-V block and AF in the elderly patients with RVHD was shown much higher.（P 0.05） Occurrence of congestive heart failure,AMI,cerebral vascular disease and syncopy was also remarkably higher. （P 0.05）； Large scale epidemiologic analysis on RVHD and vascular calcification in the elderly Study was carried on in 8202 elderly retired veterans. 820 were randomized according to age. Mobility and proportions of RVHD in the elderly Risk factors of RVHD in the elderly Correlation between RVHD and carotid athrosclerosis (CAS) Mobility of RVHD and Relative Risk Factor Relationship between Valvular Calcification and CAS Articles On RVHD and vascular calcification in the elderly Alkaline phosphatase might be an initiator of vascular calcification. High homocystine level contributes to Ectopic calcipication MMP-3 protein level was upregulated in aortic calcification,which might accelerate calcification