Herpetoviridae - Herpes Simplex Virus - Herpes Zoster ：疱疹病毒科-单纯疱疹病毒-带状疱疹.ppt

* * * Influenza A, B, C viruses ● Klasifikasi, Struktur, Genom, Kultur dan Sifat Virus - Famili Orthomyxoviridae Influenza A virus tdd : subtipe ~ 15 HA dan 9 NA ( ~ outbreaks in humans : H1-3 dan N1-2 ) - Virion berbentuk spheris, tdd : a. Segmented, minus strand RNA b. Helically coiled nucleocapsid c. Enveloped (hemagglutininneuraminidase glycoprotein spikes) * Genom :13000-15000 nt, tdd 7-8 segmen (reassortment !); menyandi 10-11 macam protein. Influenza C virus : gen NA ? Dapat dikultur pada a.l. monkey kidney cells Host : Influenza A virus : wild avian, humans, swine, horses Influenza B C virus : humans : swine, dogs, cats, horse Inaktivasi dgn : radiasi ionisasi, pH 5/9, 50?C, deterjen, drying * * - Seasonal : winter / spring (temperate) rainy (tropic) (Influenza C virus : non seasonal) - Influenza A virus : avian; ~ epidemik influenza (peran swine) : non human human (reassortment!) Influenza B C virus : ~ milder disease; winter outbreaks ● Epidemiologi - Worldwide outbreak tiap tahun pandemik : Influenza A virus H1N1 (swine) 1918, H2N2 (Asian) 1957, H3N2 (Hongkong) 1968, H5N1 (chicken/bird) 1997 1947 : WHO surveillance program * - Low mortality (~ lower respiratory/ cardiovascular disease) - Transmisi : by airborne droplets (orang ke orang, zoonotik) - Sering reinfeksi - ~ Infeksi nosokomial (Influenza A virus ) ● Manifestasi Klinis - Gejala/sindroma influenza (all age groups) - Komplikasi : sering ( otitis media/sinusitis, bronchitis, croup, pneumonia, CNS, myocarditis, gagal ginjal akut) * * ● Diagnosis Lab - Isolasi virus dari sputum, usap hidung/tenggorok, nasal aspirate/washing (kultur sel) deteksi CPE