男性乳房发育课件_1.pptVIP

Drug-induced gyncomastia Spironolactone: inc. aromatization of T to E2, decrease T production by testes, displace T from SHBG – inc. clearance rate, bind to androgen rct, displace or prevent binding of T or DHT to rct. Low dose 25-50 mg/d: 10% compared with 3% in placebo group Almost all pts using =100 mg/d CCB: nifedipine – highest frequency; diltiazem – lowest. H2RA or PPI: Cimetidine ranitidine omeprazole Drug-induced gynecomastia AIDS patients using HAART Usually due to increase in adipose tissue (pseudomgynecomastia), part of fat redistribution syndrome (lipodystrophy) Efavirenz: estr