基础医学第十抗原提呈细胞和抗原提呈.pptVIP

100 50 75 25 0 % of max. T cell response 10-1 10-2 10-3 Antigen ?gml-1 Receptor-mediated antigen uptake Non-receptor -mediated uptake Receptor-mediated uptake enhances the efficiency of the T cell response * Proteases produce ~24 amino acid long peptides from antigens Drugs that raise the pH of endosomes inhibit antigen processing Endosomes Exogenous pathway Increase in acidity Cell surface To lysosomes Uptake Protein antigens In endosome Cathepsin B, D and L proteases are activated by the decrease in pH * Activation of Cathepsin B at low pH At higher pH cathepsin B exists in a pro-enzyme form