阿尔茨海默病额叶白质损害的ti与临床执行功能的关系论文.docVIP

华　 中　 科　 技　 大　 学　 硕　 士　 学　 位　 论　 文 阿尔茨海默病额叶白质损害的DTI与临床执行功能的关系　 　 中文摘要　  目的  分别应用磁共振扩散张量成像(DTI)及额叶功能评定量表(FAB)评价阿尔茨  海默病(AD)患者额叶白质损害与执行功能  并对两者的关系进行研究  方法  对 25 例 AD 患者和 25 例健康对照者应用 FAB 测得评分  并且进行 DTI  扫描  测量额叶白质的部分各向异性(FA)和平均扩散系数(ADC)值  应用独立样本 t  检验对 AD 组和正常对照组的额叶白质区域的 FA 值和 ADC 值及两组的 FAB 评分进 行比较 并应用 Pearson 相关分析评价额叶白质的 FA 值和 ADC 值与临床执行功能评 分之间的相关关系  结果  AD 患者 FAB 值及额叶白质 FA 值均较对照组显著降低  额叶白质 FA 值  与 FAB 值呈正相关（r　＝0.678  P  0.003）  结论  FAB 能够实用且有效的检测 AD 患者额叶执行功能的改变  FA 值可反映  AD 患者额叶白质受损程度及其与执行功能的关系  关键词  阿尔茨海默病　　执行功能障碍　　扩散张量成像　　额叶功能评定量表 1 华　 中　 科　 技　 大　 学　 硕　 士　 学　 位　 论　 文 Correlation between the MR DTI of the frantal white matter damage and the clinical executive function in patients with Alzheimer’s disease ABSTRACT OBJECTIVE: To determine the relationship between the frantal white matter damage and the executive function in AD by using DTI and the Frontal Assessment Battery (FAB) respectively. METHODS: The executive function of twenty fifteen patients with AD and twenty fifteen age- matched-healthy volunteers were graded by FAB. AD and controls received MR-diffusion tensor scanning to measure the fractional anisotropy (FA) and the apparent diffusion coefficient (ADC) in the frantal white matter. Independent-samples t-test was used to test differences between AD and controls for FAB scores, FA and ADC values. Pearson correlation analysis was applied to reveal the relationships between FA values in the frantal white matter and the FAB scores. RESULTS: There was statistically significant difference in the FA values of the frontal white matter and the FAB scores between AD and controls. Positive correlations were found between the FA values in the frontal white matter and the FAB scores (r =0.678 P=0.003). CONCLUSIONS: In AD, FAB is easy and useful to administer to measure the executive dysfunction of the fontal lobe at bedside. The MR-DTI can reflect the relationship between the degree of white matter abnormalities and the executive dysfunction.