痢疾Bacillary ysentery课件.pptVIP

Bacillary Dysentery (shigellosis) Definition Acute infectious disease of intestine caused by dysentery bacilli(genus shigella) Place of lesion: sigmoid rectum Pathological feature: diffuse fibrious exudative inflammation Definition Clinical manifestation: fever, abdominal pain, diarrhea, tenesmus , stool mixed with mucus blood, pus. even companied with shock, toxic-encepholopthy. Etiology Causative organism: dysentery bacilli, genus shigella, gram-stained negative, non-motile short rod, Groups: 4 serogroups 47 serotypes Etiology S. dysenteriae: the most severe S. flexneri: the epidemic group and easily turn to chronic S. boydii: tropical and subon S. sonnei: the most mild Etiology Pathogenicity: - virulence endotoxin - exotoxin - invasiveness (attach-penetrate-multiply) Resistance: Strong, 1-2week in fruits,vegetable and dirty soil, heat for 60℃ 30 min Epidemiology Source of infection: patients and carriers Route of transmission: fecal-oral route Suceptibility of population: immunity after infection is short and unsteady, no cross-immune Epidemiology Epidemic features: season: summer fall Flexneri, Soneii, dysentery age: younger children Pathogenesis number of bacteria toxicity invasiveness attachment penetration multiplication immunity Pathology site of lesion: entire large bowel- sigmoid colon rectum feature: acute: diffuse fibrinous exudative inflammation, Pathology hyperemia, edema, leukocyte infiltration, superficial necrosis, ulcer. chronic: edema, polypoid hyperplasia, toxic: colon: hyperemia, edema, micro- capillary was invaded Clinical manifestation Incubat