DKI英文PP简介课件.ppt

Monitoring postnatal brain maturation by DKI Both λ// and K// of WM are found to increases with age, which may arise from various biological events during early postnatal brain maturation. The increase of diffusivity can be caused by axoplasmic flow during the myelination period neuronal loss and axonal pruning that shortens the axon length can lead to an increase of restriction Monitoring postnatal brain maturation by DKI The increase of K⊥ in WM is likely ascribed to the myelination and modification of axonal structures that increases restriction in the radial direction. DKI analysis also reveals that diffusion restriction in the relatively isotropic GM increases with age. This may reflect the more densely packed structures and the dendritic architectural modification in GM DTI VS DKI in monitoring postnatal brain maturation When there is a large K, the estimated diffusivity in conventional DTI shows a large discrepancy with the diffusivity estimated in DKI approach. As K in all the structures is positive, DTI-derived diffusivities are generally lower than those by DKI. The relatively high sensitivity of the λ⊥ in monoexponential DTI model is mainly a result of increasing K ⊥ with age (while the changes of λ ⊥ in DKI are moderate). DTI VS DKI in monitoring postnatal brain maturation DTI-derived λ// is related to the increase of both K// and λ// derived in DKI that manifests opposite and competing effects. herefore diminished sensitivity in detecting maturational changes of λ// in conventional DTI are observed. The separation of λ// and K// can improve the characterization of neural tissue along the axial direction. Because the complex biological modification of WM along axonal direction affects both diffusivity and kurtosis, information obtained in conventional DTI is inadequate to fully infer the microstructural changes during brain maturation. Other applications DKI may serve as a more sensitive tool to detect and characterize such subtle change