大脑变弥散成象.pptVIP

Residual Medulloblastoma - PICA Infarct Observations inverse relationship between tumor cellularity and ADC low ADC in infection due to high viscosity, inflammatory cells, mucoid protein, cellular debris, and water binding to fibrinogen low ADC in acute infarct, higher ADC in subacute/chronic infarct similar ADC values for acute infarct, infection, and malignancy * Diffusion Imaging in Cerebral Diseases YANG ZHIYUN, MD The 1st Hospital Of Sun Yetsen University ,Guangzhou, China Diffusion Imaging ? ?? exploits the random translational mobility of water molecules to obtain information on the microscopic behavior of tissues ?? applies equal and opposite gradients on either side of a refocusing lobe in a standard pulse sequence proton in tissue without motion is initially dephased and becomes rephased by the opposite gradient mobile protons are not rephased and lead to drop in signal intensity amount of signal loss is a marker of interstitial movement of water and allows indirect evaluation of tissue structure Factors Affecting Water Diffusion In Living Tissue ? cellular compartmentalization cell type and number cell membrane density and permeability macromolecule size and type tissue viscosity tissue temperature tissue perfusion Patients Method 117 children with 260 space occupying lesions (72 boys, 39 girls, age range newborn-17 years, mean 8.26 years) CP head coil, 1.5T (Siemens Symphony) axial SS EPI, echo factor 128 TR/TE 220/139, 19 slices, 5mm thick, 1.5 mm gap b = 0, 900 mm2/sec in three directions, phase direction AP 22 cm FOV, 128x128 matrix interpolated to 256x256 4 averages, acquisition time 50 sec, bandwidth 1346 Hz/pixel Trace image - diffusion-weighted imaging in three axes and post-processed as an expression of its natural logarithm ADC = -1/(b1 - b2) x ln (S1/S2) S1 and S2 - mean signal intensities in the regions of i