FOLFOX方案治疗晚期大肠癌的临床观察.docVIP

FOLFOX4方案治疗晚期大肠癌的临床观察 肿瘤防治杂志2ooj:生旦笙鲞笙塑旦:兰垦::垦::!11!!:: FOLFOX4方案治疗晚期大肠癌的临床观察 应杰儿,钟海均,冯海洋 浙江省肿瘤医院化疗中心,浙江杭州310022 《基础?临床研究l 【摘要】为了探讨FOIFOX4方案治疗晚期大肠癌的疗效和安全性.对37例初治或复治的晚期大肠癌患者,予FOI FOX4方案化疗.全组37例均可评价疗效,初治组部分缓解(PR)7例,稳定(SD)13例,进展(PD)1例,客观有效率为 33.3,中位疾病进展时间8个月,中位生存期14个月;复治组PR3例,SD¨例,PD2例,客观有效率为18.8,中位 疾病进展时间4个月,中位生存期7个月.毒副反应主要为中性粒细胞减少,消化道反应和神经毒性,均以I～Ⅱ度为 主,可耐受.初步临床观察结果表明,FOIFOX4方案治疗晚期大肠癌疗效肯定,安全性好,值得积极推广. ● 肿瘤防治杂志,2005,12(18):1423—1{24 ClinicalstudyofFOLFOX4regimenintreatmentofadvancedcolorectalcancer YINGJie—Pr,ZHONGHai—jun.FENGHai—yang DepartmentofChemotherapy,ZhejiangTumorHospital.Hangzhou310022,P.R.China [-ABSTRACT~TheobjectiveofthisstudywastoevaluatetheefficiencyandtoxicityofFOIFOX4regimeninthe treatmentofadvancedcolorectalcancer.Thirty—sevenpatientswithadvancedcolorectalcancerwhohadnotbeentrea— tedbychemotherapyorhadbeenuntreatedwereenrolled.Thecycleswererepeatedevery14days.Allpatientsre— ceivedtwoormorecycles.Resultsall37patientswereevaluatedforefficiencyandtoxicity.Intheuntreatmentpa— tients,theresponseratewas33.3,including7partialresponse(PR),13stabledisease(SD)and1progressdis— ease(PD);themediantimetotumorprogressionwas8months,andthemedianoverallsurvivalwas14rnonths.In thetreatmentpatients,theresponseratewas18.8,including3PR,11SDand2PD;themediantimetotumor progressionwas4months,andthemedianoverallsurvivalwas7months. Themajortoxicitieswereneutropenia.gas trointestinaltoxicityandneurotoxicity,andmostofwhichwereI—IIgrade.FOIFOX4regimeniseffectiveand welltoleratedforpatientswithadvancedcolorectalcancer. (l”11J(“aricer尸revTrea,,2005.12(18).1I23—12-1 【关键词】结直肠肿瘤/药物疗法;氟尿嘧啶/投药和剂量;醛氢叶酸/投药和剂量;有机铂化舍物/投药和剂量;抗肿瘤联 合化疗方案 [-KEYWORDS~colorectalneoplasms/drugtherapy;fluorouracil/administrationamp;dosage;leucovorin/administrationamp; dosage;organoplatinumcompounds/administrationamp;dosage;antineoplasticcombinedchemotherapyprotoco1s 结直肠癌是发病率逐年增加的恶性肿瘤,全球发病率居第 3位,死亡率居第4位_1l,我国结直肠癌发病率和死亡率也呈上 升趋势,结直肠癌5年生存率为4O～6O,超过一半的患者 在疾病过程中出现远处转移],故药物治疗非常重要.白2002 年以来我们以FOIFOX4方案治疗晚期大肠癌,取得了较好疗 效,结果总结报道