胆汁淤积症诊断治疗.pptVIP

Steroid Receptor Action Cytoplasm HRE Nucleus Ligand SR SR SR SR SR mRNA Protein Cell specific Response 1 TF TF SR 2 J Hepatol 2007; 46 : 365–371 po 骨质疏松症的治疗 脂溶性维生素缺乏 Hepatology 2009; 40: 291 * 根据其发生部位的差异分为肝内胆汁淤积和肝外胆汁淤积，肝外胆汁淤积最常见的原因是机械性阻塞；肝内胆汁淤积的原因则更为复杂，包括感染性、药物性、自身免疫性、妊娠性等，但有时两者可有交叉，如原发性硬化性胆管炎（PSC）可同时有肝外和肝内部分的病变。 * In 1989, a panel of 12 European and American experts7 by consensus defined liver injury as an increase of more than twice the upper limit of the normal range in the levels of serum alanine aminotransferase or conjugated bilirubin, or a combined increase in the levels of asparta