曲美他嗪对稳定型心绞痛患者疗效及对运动耐量影响.docVIP

曲美他嗪对稳定型心绞痛患者疗效及对运动耐量影响 　　[摘要] 目的 探讨曲美他嗪对稳定型心绞痛患者疗效及对运动耐量的影响。方法 回顾性分析我院2011～2013年心内科收治的300例稳定性心绞痛患者的资料，按照患者治疗方式分为观察组及对照组，各150例，两组患者均给予β受体阻滞剂、阿司匹林、氯吡格雷、钙通道拮抗剂、他汀类常规药物治疗，观察组加用曲美他嗪片，连续治疗2周，对患者进行运动耐量测定，对两组患者治疗后临床症状及运动耐量进行评价。结果 观察组患者临床总有效率高，与对照组患者比较差异有统计学意义（P　　[关键词] 曲美他嗪；稳定性心绞痛；运动耐量 　　[中图分类号] R541.4 [文献标识码] B [文章编号] 2095-0616（2013）24-66-03 　　Effect of trimetazidine on curative effect and exercise tolerance in patients with stable angina cordis 　　ZHENG Xiaohua WU Luxi ZHU Jingwei LIN Zichuan MA Hezhou 　　Department of Cardiology，the Peoples Hospital of Taishan City，Taishan 529200，China 　　[Abstract] Objective To investigate the effect of trimetazidine on curative effect and exercise tolerance in patients with stable angina cordis. Methods The information of 300 patients with stable angina cordis from 2011 to 2013 in the cardiology department of our hospital were retrospectively analyzed. All patients were divided into the observation group and the control group according to the different treatment methods， and each group had 150 cases. The patients of the two groups were both given the conventional drugs treatment， such as beta-blockers， aspirin， clopidogrel， calcium channel blockers， statins， while the patients of the observation group were added with trimetazidine treatment for 2 weeks， and the exercise tolerance of patients were measured. The clinical symptoms and exercise tolerance of patients in the two groups were evaluated after the treatment. Results The clinical total effective rate of the observation group was higher than that of the control group， the difference was statistically significant（P0.05）。 　　1.2 入选标准 　　入选患者符合2007年《稳定性心绞痛诊断和治疗指南》及《缺血性心脏病的命名及诊断标准》，年龄在50～70岁，患者因运动或增加心肌耗氧量的情况诱发的短暂胸痛，舌下含化硝酸甘油或休息后，疼痛可消失；病程稳定≥1个月；每周发作≥2次，既往行冠状动脉造影、CTA、运动试验心电图确诊。排除重度心肺功能不全、重度心律失常（阵发性室速Ⅱ度Ⅱ型及Ⅲ度房室传导阻滞）[3]。 　　1.3 方法 　　两组患者均给予常规治疗，包括严格卧床休息，严密监护，吸氧及抗心绞痛治疗（β受体阻滞剂、阿司匹林、氯吡格雷、钙通道拮抗剂、他汀类）。观察组患者加用曲美他嗪片（万爽力，YB20mg，3次/d，连续治疗2周。2周后对患者临床疗效进行评价。患者治疗结束后进行运动平板试验，Marguette case15型平板运动