IGF2R在非小细胞肺癌中表达及与肿瘤进展相关性研究.docVIP

IGF2R在非小细胞肺癌中表达及与肿瘤进展相关性研究 　　 　　[摘要] 目的 探讨胰岛素样生长因子2受体（IGF2R）在非小细胞肺癌（NSCLC）组织中的表达情况与临床病理因素的关系。 方法 收集80例NSCLC组织及10例癌旁正常肺组织石蜡标本制成切片，利用免疫组织化学染色（SP）法检测IGF2R的表达，并分析其与各种临床病理因素的关系。 结果 IGF2R主要定位于细胞膜及细胞质，80例NSCLC组织中，46例（57.5%）为高表达，在非癌性肺组织中弱表达或无明显表达。IGF2R表达同低级别pTNM分期（P=0.038）、局部淋巴结转移减少（P=0.021）相关。 结论 IGF2R的表达与NSCLC低级别pTNM分期、局部淋巴结转移减少相关。 　　[关键词] 胰岛素样生长因子2受体；非小细胞肺癌；肿瘤标志物；免疫组织化学 　　[中图分类号] R734.2[文献标识码] A[文章编号] 1674-4721（2014）04（c）-0012-03 　　 　　Correlation study of IGF2R expression in non-small cell lung cancer and tumor progression 　　ZHANG Min1 HUANG Bo2 ZHANG Ling1 LV Wei-li1 　　1.Department of Pathology,College of Basic Medical Sciences,Shenyang Medical College,Shenyang 110034,China;2.Department of Pathology,Liaoning Cancer Hospital,Shenyang 110042,China 　　[Abstract] Objective To explore the clinical significance of insulin-like growth factor 2 receptor (IGF2R) in patients with non-small cell lung cancer (NSCLC). Methods Paraffin-embedded specimens from 80 patients with non-small cell lung cancer and 10 normal lung tissues adjacent to the cancer tissues were collected.The expressions of IGF2R protein were detected by immunohistochemistry,and its relationship with various clinical pathological factors was analyzed. Results IGF2R mainly located in cell membrane and cytoplasm,among 80 lung cancer specimens,46 samples showed high expression levels of IGF2R (57.5%),IGF2R was not detected or weakly positive stained in nonneoplastic lung specimens.High expression of IGF2R was correlated with low pTNM (P=0.038) and reduced lymph node metastasis (P=0.021). Conclusion High expression of IGF2R correlate with low pTNM and reduce lymph node metastasis in NSCLC. 　　[Key words] IGF2R;Non-small cell lung cancer;Tumor marker;Immunohistochemistry 　　胰岛素样生长因子2受体（insulin-like growth factor 2 receptor，IGF2R）属于Ⅰ型膜整联蛋白，稳定状态下，约90%的IGF2R定位于细胞内，其余10%位于细胞膜表面，其对于胰岛素样生长因子2（insulin-like growth factor 2，IGF-2）等配体具有高亲和性，对肿瘤的发展可起到抑制作用[1-3]。IGF2R蛋白在非小细胞肺癌（non-small cell lung cancer，NSCLC）组织中的表达情况及意义目前尚无报道，本实验将探讨I