个体化医疗现状与未来蛋白质组学.pptVIP

个体化医疗的现状与未来三. 蛋白质组学研究 吕林莉 M.D., Ph.D. 东南大学医学院 Outline Why we study proteome? What is proteome? How to study proteome? Proteomics and disease Why we study proteome? Why we study proteome?为何要研究蛋白质组？ Gene expression not correlates with protein All proteins have life and death cycle Structure and chemistry property of protein is more complex (1) Gene expression not correlates with protein The abundance of cellular protein is affected by: (a) DNA transcription rate (转录效率）(codon bias)（密码子偏倚） (b) mRNA translation rate（翻译效率） (c) Protein degradation rate（降解效率） Apparent poor relatio