氟比洛芬酯超前镇痛在门诊宫腔镜手术中应用.docVIP

氟比洛芬酯超前镇痛在门诊宫腔镜手术中应用 　　【摘要】 目的 观察氟比洛芬酯超前镇痛在门诊宫腔镜手术中的作用效果。方法 40例宫腔镜手术患者随机分为两组,丙泊酚组(P 组)和氟比洛芬酯(F组),每组各20 例。F组在麻醉前10 min静脉注射氟比洛芬酯50 mg。两组均静脉注射丙泊酚2 mg/kg麻醉诱导,术中麻醉维持采用丙泊酚6~8 mg/(kg#8226;h)恒速输注,术中出现体动追加注射丙泊酚20 mg。记录两组患者的睫毛反应消失时间、苏醒时间、自动坐起时间及不良反应。结果 F组患者的自动坐起时间明显短于P组(P0.05)。F组患者术后恶心的发生率低于P组(P0.05),而头晕的发生率高于P组(P0.05)。结论 氟比洛芬酯超前镇痛用于门诊宫腔镜手术中,具有良好的恢复质量,可缩短门诊宫腔镜患者的就诊时间,并降低术后恶心的发生率。 　　【关键词】氟比洛芬酯;宫腔镜下手术;超前镇痛 　　 　　Application of flurbiprofen preemptive analgesia combined with intravenous propofol anesthesia in outpatient hysteroscopy 　　CHEN Xiang nan,HUANG Xi zhao,HU Zu rong,et al.Department of Anesthesiology,Guangdong Women and Children’s Hospital,Guangzhou,510010,China 　　【Abstract】 Objective To investigate the effect of flurbiprofen preemptive analgesia combined with intravenous propofol anesthesia in outpatient hysteroscopy.Methods 40 women(ASA class I)undergoing hysteroscopy were randomly divided into propofol group(P group)and flurbiprofen group(F group).All groups had intravenous induction with 2 mg/kg propofo1 and maintained with 6 8 mg/kg/h propofol.In F group,the patients were given 50 mg flurbiprofen 10 min before the operation.The eyelash reflex vanished time,recovery time,auto sitted time and adverse effect were recorded.Results The auto sitted time was shorter in F group than that in P group.F group had lower incidence of nausea than P group,but had higher incidence of dizziness than P group.Conclusion Flurbiprofen preemptive analgesia combined with intravenous propofol have good recovery and can reduce the visiting hospital time of patients in hysteroscopy. 　　【Key words】Flurbiprofen; Pre emptive; Hysteroscopy 　　 　　宫腔镜是一种最常用的诊断和治疗子宫和内膜疾病的方法[1]。虽然宫腔镜检查的时间较短,但是当扩宫和子宫内组织物取出时可引起严重的疼痛[2]。丙泊酚因其起效快、恢复迅速等优点,常用于宫腔镜检查及手术,但其镇痛效果较差,常需配伍镇痛药。氟比洛芬酯注射液(凯纷)是一种新型的非甾体抗炎镇痛药脂微球制剂,具有靶向镇痛作用。本研究拟探讨氟比洛芬酯超前镇痛在门诊宫腔镜手术中的可行性及作用效果。 　　1 资料和方法 　　1.1 一般资料 选取ASA I~Ⅱ级拟行宫腔镜手术的患者40例,年龄25~45岁,体质量45~65 kg。随机分为两组,丙泊酚组(P 组)和氟比洛芬酯(F组),每组各20 例。既往无心肺疾病史,无内分泌疾病史,无药物过敏史,术前心电图、血常规均正常。排除消化道溃疡史,哮喘史;非甾体类抗炎镇痛药过敏的患者;正