口腔医学中得抗生素应用（英文）Antibiotic Use In Dentistryppt课件.pptVIP

Antifungals Nystatin MOA: inhibit cell wall synthesis Dose: 5 ml swish and swallow q 4 h x 10-14 d GI upset Drug interactions: minor Pregnancy category C 代理报关委托书委托报关协议关于审理城镇房屋租赁合同纠纷案件司法解释有关劳务派遣制度设计及对劳务派遣行业的影响分析糖皮质激素在呼吸系统疾病中的合理应用严重脓毒症导致急性肺损伤病人自发利尿现象的观察分析 Antibiotic Use In Dentistry Kevin Nakagaki, D.D.S. Director, Hospital Dental Clinic University of Minnesota Writing Prescriptions Rx: Drug Name (can be generic) Unit Dose (ex: Pen V-K 500 mg, Elixer, Sol’n) Disp: # of pills, milliliters (ml) Sig: Directions for use. q24h (daily), q12h, q8h, q6h, q4h, prn pain, till gone Refills__ Signature DEA # General Rules Write Legibly!! Remember your audience (Generally non-docs) this will improve compliance. Preferable to order specific hourly dosage time (q12h vs. bid, q8h vs. tid, etc.) Sig: Specify # of pills to take each dose Prescribe an endpoint. (prn pain, till gone) Antibiotic Strategies Cardinal Rules: 1) Use the right drug. 2) Use the right dose. 3) Use the correct dosing schedule. 4) Correct duration. Hard and Fast—Especially early. Why? Use a loading dose to rapidly achieve therapeutic blood levels. Avoid combinations of bacteriostatic and bacteriocidal drugs. Considerations Gram Positive? Gram Negative? Mixed Infection? Anaerobes? Discussion: Antibiotic Choice Narrow Spectrum? Extended/Broad Spectrum? Designer Antibiotics? Anaerobes? Consider if the infection is present 3days or if no improvement. Narrow Spectrum Antibiotics Specific for the pathogen. Fewer disturbances of non-pathogenic bacteria. Fewer side effects. Rapid response for sensitive organisms. Ex: Pen VK, Pen G, Erythromycin Broad Spectrum Antibiotics Affects both Gram + and Gram – bacteria, better for mixed infections. May give up some effectiveness for Gram + to gain effectiveness for Gram -. Examples: Amoxicillin, Ampicillin Common Pathogens Necrotic pulp and apical abscesses Obligate anaerobic bacteria Gram negative rods Prevotella porphyomonas spp. Fusobact