啉及其n-烷基衍生物的合成工艺总结.pdfVIP

Hans Journal of Chemical Engineering and Technology 化学工程与技术, 2017, 7(1), 31-37 Published Online January 2017 in Hans. /journal/hjcet /10.12677/hjcet.2017.71005 Overview on the Synthesis of Morpholine and Its N-Alkyl Derivatives 1* 1,2 2 1,2 1 1 Beibei Zhu , Qi Zhang , Suolian Shi , Xiaoming Ye , Chao Qian , Xinzhi Chen 1 Zhejiang Provincial Key Laboratory of High Efficiency Chemical Engineering Manufacturing Technology, College of Chemical Engineering and Bioengineering, Zhejiang University, Hangzhou Zhejiang 2 Sichuan Zhijiang High-Tech Material Co., Ltd., Suining Sichuan st th nd Received: Jan. 1 , 2017; accepted: Jan. 19 , 2017; published: Jan. 22 , 2017 Abstract Morpholine and its N-Alkyl derivatives are a class of important intermediates for many fine chem- icals, which have been widely used in rubber, medicine, pesticide and other fields. This paper summarized several methods to synthetize these compounds according to their structural cha- racteristics: the etherification of C-O-C bond linkage, the amination of C-N-C bond linkage and the N-alkylation of morpholine. The features of each method were analyzed. Finally, the development in the synthesis technology of morpholine and its N-alkyl derivatives was proposed. Keywords Amine, Etherification, Amination, N-Alkylation 吗啉及其N-烷基衍生物的合成 工艺总结 1* 1,2 2 1,2 1 1 竺贝贝 ，张 琪 ，施锁连，叶小明 ，钱 超 ，陈新志 1浙江大学化学工程与生物工程学院，浙江省化工高效制造技术重点实验室，浙江 杭州 2 四川之江高新材料股份有限公司，四川 遂宁 收稿日期：2017年1月1 日；录用日期：2017年1月19 日；发布日期：2017年1月22 日 *通讯作者。 文章引用: 竺贝贝, 张琪, 施锁连