2014血小板减少性紫癜发病机制ppt课件.pptVIP

;发病机制—体液免疫;发病机制—体液免疫;发病机制—体液免疫;发病机制—体液免疫;发病机制—体液免疫;发病机制—体液免疫;血小板膜糖蛋白（glycoprotein, GP）特异性自身抗体;发病机制—细胞免疫;;Although the immuopathogenesis of chronic autoimmune thrombocytopenic pupura is autoantibody mediated, it is a primarily a T cell-initiated disorder. ;T Cell Characteristics:;Approximately 40% of patients with chronic AITP have no detectible antibodies on their platelets or in their plasma. ;Tumor cell;Anderson et al. Nature Medicine 2003 ;Disturbed apoptosis of T-cells in patients with active idiopathic thrombocytopenic purpura apoptotic resistance of activated T-lymphocytes in pat