医学ppt课件_《医用基础药理学》_5.pptVIP

;Introduction the action of thyroid hormones the pharmacological effects, clinical uses and untoward reactions of thiourease the action and uses of iodides and radioiodine ;; 1. Uptake of Iodide . 2. Oxidation and Iodination 3. Formation of Thyroxine (T4)and Triiodothronine(T3) from Iodotyrosines;;;3. Formation of Thyroxine and Triiodothronine from Iodotyrosines Coupling of two DIT to form Thyroxine(T4) Coupling of one MIT and one DIT to form Triiodothronine(T3);Secretion of Thyroid hormones;Regulation of Thyroid Function; Actions of Thyroid hormones; What is Cretinism? Cretinism is often encountered in regions of endemic goiter and is usually caused by extreme deficiency of iodine The child is dwarfed , with short extremities and is mentally retarded;Clinical uses of Thyroid hormones Hypothyroidism Myxedema Cretinism Endemic Goiter ;Antithyroid agents Thioureas Iodides Radioiodine Beta blocking agents;Thioureas Drugs methylthyioracil（甲基硫氧嘧啶） propylthiouracil (丙基硫氧嘧啶) methimazole tapazole (甲巯咪唑，他巴唑) carbimazloe（卡比马唑，甲亢平） ;2. Pharmacological effect prevent the thyroid hormone synthesis by inhibiting the thyroid peroxidase-catalyzed reactions to block iodine organification. block coupling of iodotyrosine, mainly the formation of DIT. ;Therapeutic applications Hyperthyroidism ??????Preparation for thyroid surgery Supplementary treatment of thyrotoxic crisis 甲状腺危象 ;4. Adverse reaction skin rash, enlargement of lymph glands and jaundice. agranulocytosis 粒细胞缺乏症. serious adverse reaction Fetal hypothyroidism. ; Iodides 1. Pharmacologic effect Large dose Inhibit organification, inhibit hormone release, and decrease the size and vascularity of the hyperplastic gland. Iodides inhibit hormone release, possibly through thyroglobulin proteolysis. Small dose？ ;; Radioiodine 1. Pharmacologic properties emit both beta