SKIN DISEASES Shanyar大疱性皮肤病ppt课件.pptVIP

Bullous Skin Disorders (BSD);INTRODUCTION;;PATHOPHYSIOLOGY;;Types: Genetic Blistering Diseases: A. Epidermolysis Bullosa B . Hailey-Hailey disease ( Benign familial pemphigus) 2. Immunobullous Diseases: A. Intraepidermal Immunobullous Diseases: 1.Pemphigus Vulgaris (PV) 2. Pemphigus vegetans . 3. Pemphigus foliaceus 4. Pemphigus erythematosus 5. Paraneoplastic P B. Subepidermal Immunobullous Diseases: 1.Bullous Pemphigoid 4. Pemphigoid Gestations 2. Linear IgA disease 5. Epidermolysis Bullosa Acquisita 3. Dermatitis Herpitiforms ;IMMUNOLOGIC BULLOUS SKIN Dis.;PEMPHIGUS;Epidemiology ;AETIOLOGY;CLINICAL FEATURES;Mouth ulcers in PV { appear 1st in most cases };; + ve Nikolski’s Sign; Clinical evaluation Histopathologic by Light microscopy Immunofluorescent examination. is a laboratory technique for demonstrating the presence of tissue bound and circulating antibodies Electron microscopic examination ;(EM) NOT routinely done ;Pemphigus Vulgaris : Dermatopathology by Light microscopy; skin Biopsy from the edge of a blister;;Pemphigus Vulgaris ;Immunofluorescence;DDx;TREATMENT;COMPLICATIONS;PARANEOPLASTIC PEMPHIGUS (PNP);Drug-induced PV;Pemphigus vegetans in the axilla, some intact blisters can be seen;Pemphigus Vegetans;Pemphigus Vegetans;BULLOUS PEMPHIGOID;PATHOGENESIS;BULLOUS PEMPHIGOID;;CLINICAL FEATURES;INVESTIGATIONS;;;DDx;TREATMENT;COMPLICATIONS;DIFF BTW PEMPHIGUS AND PEMPHIGOID;Dermatitis Herpetiformis (DH);;CHRONIC BULLOUS Disease OF CHILDHOOD;;CLINICAL FEATURES;INVESTIGATION;TREATMENTS;;