三种民族药物化学成分抗氧化及抗菌活性的分析-analysis of antioxidant and antibacterial activities of chemical constituents of three ethnic medicines.docxVIP

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三种民族药物化学成分抗氧化及抗菌活性的分析-analysis of antioxidant and antibacterial activities of chemical constituents of three ethnic medicines.docx

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三种民族药物化学成分抗氧化及抗菌活性的分析-analysis of antioxidant and antibacterial activities of chemical constituents of three ethnic medicines

三种民族药物有效成分抗氧化及抗菌活性的研究三种民族药物有效成分抗氧化及抗菌活性的研究 antioxidant activity which is similar to that of standard antioxidant ascorbic acid (VC) and therefore may be a promising natural antioxidant. Epicatechin exhibited powerful scavenging activities against DPPH and hydroxyl radicals with IC50 values of 2.83 μ g /mL and 0.18 μ g /mL, respectively, and the ABTS scavenging activity of 2 (TEAC = 1.38 ± 0.05) was found to significantly higher than that of Trolox. The antibacterial activities and the MICs (minimal inhibitory concentration) of the tested compounds were determined through broth microdilution method. It was found that Garcinia xanthochymus exhibited strong antibacterial capacity. Compounds 5 (Symphoxanthone) and 14 (1,5,6,5-tetrahydroxy-7,8–di(3- methyl-2-butenyl)-6, 6-di- methylpyrano(2,3:3,4) xanthone) showed effective inhibitory activities against three bacteria strains (S. aereus, B. subtilis and B. mucilaginosus). And obviously, the antibacterial activities of the tested compounds were more sensitive to C. tropicalis than C. albicans. The compounds 6 (Garcinenone D), 22 (Garcinexanthone E), 25 (2-methylbutyryl phloroglucinol), 29 (1,4-Dihydroxy-6,6-dimethylpyrano (2,3:5,6) xanthone), 30 (1-dihydroxy-4,5-methoxyxanthone) showed the strongest activities against C. albicans with MIC value of 31.25μg/mL, and both the MIC value of compounds 14 (1,5,6,5-tetrahydroxy-7,8–di(3-methyl-2-butenyl)-6, 6-dimethylpyra- no(2,3:3,4) xanthone) and 18(Subelliptenone H) against C. tropicalis was 3.91μg/mL. Key Words: Garcinia xanthochymus, Fissistigma polyanthum, Microcos paniculata L., antioxidant activities, antibacterial activities IV 中南民族大学硕士学位论文中南民族大学硕士学位论文英文缩写检索 MIC： minimal inhibitory concentration MBC：minimal bactericidal concentration ESR：electron spin resonance EPR： electron paramagneticreonance, TAA： total antioxidant activity, DPPH： 1,1-diphenyl-2-picrylhydrazyl TEAC：trolox equivalent antioxidant capacity TRAP：Total peroxyl radical-trappin