肿瘤的转移与侵袭ppt课件.pptVIP

侵袭与转移 -肿瘤防治的关键 方伟岗 北京大学医学部 2009.4;World Cancer Report (2008);前十位恶性肿瘤死亡率(合计);5年生存率;关键问题;CA Cancer J Clin 2008;淋巴路转移;肿瘤转移的器官亲和性;胃癌转移至双侧卵巢;Langley RR and Fidler IJ. Endocrine Rev 2007 ;;The conceptual framework of metastasis ;;Kopfstein L. Cell. Mol. Life Sci. 2006 ;Key steps in cancer metastasis;Adhesion Molecules;adhesion molecules implicated in tumor metastasis;Cell adhesion molecule superfamily;CAMs involved in colorectal liver metastasis ; Loss of adhesion Regulation of proteinase synthesis Survival in blood stream Organ-specific metastasis;Proteolysis and ECM degradation;降解ECM的蛋白水解酶;Ma