机体对酸碱平衡的调节机制及代谢性酸中毒ppt课件幻灯.pptVIP

Proximal RTA Clinical Feature May accompany Fanconi syndrome HCO3- fractional excretion :15% Urine PH 5.5 during severe acidosis HCO3- reabsorption threshold change Proximal RTA Laboratory finding hyperchloremic acidosis hypophosphatemia alkaline phosphatase elevation hypokalemia, hypouricemia urine glucose, amino acid, phosphorous Proximal RTA Treatment restore systemic acidosis:10-25 mEq/kg/day treatment of osteomalacia: VitD correct hypokalemia: potassium salt Classic Distal RTA Major Causes: Autoimmune disorder Hypercalciuria and Nephrocalcinosis Drug or Toxin Tubulointer