一氧化氮供体对穿膜肽吸收课件.pptxVIP

Nitric oxide donors can enhance the intestinal transport and absorption of insulin and [Asu1,7]-eel calcitonin in rats;The characteristics of three NO donors, NOC5 NOC12 SNAP as absorption enhancers for peptide drugs were examined in rats . Insulin and [Asu1,7]-eel calcitonin (ECT) were used as a model drug to investigate the effectiveness of the tested enhancers. Experimental method：a modified Ussing chamber method and an in situ closed loop method. Conclution： NO donors possess excellent effectiveness for the use as absorption enhancers of peptide drugs and they are very effective at