《肿瘤免疫研课程班》ppt课件.pptxVIP

肿瘤免疫 Tumor Immunity;Model of sequential genetic alterations leading to metastatic colon cancer. Each of the stages indicated at the bottom is morphologically distinct, allowing researchers to determine the sequence of genetic alterations.;一、肿瘤特异性抗原 二、肿瘤相关性抗原;化学和物理致癌因素诱发的肿瘤抗原 病毒诱发的肿瘤抗原 癌基因和突变型抑癌基因表达的肿瘤抗原 正常静止基因表达的肿瘤抗原 ; Mice were induced to produce tumors by the injection of a chemical carcinogen (methyl-cholanthrene). Tumor cells from these mice were then injected subcutaneously into genetically identical mice. Later, the growing tumor were removed surgically. Mice challenged with the same tumor were able to reject it, but those challenged with a different tumor (induced with the same carcinogen) were not. The ability to reject the tumor could be transferred with lymphoid cells.; Experimental induction of immunity against tumor cells induced by polyoma virus(PV);癌基因和突变型抑癌基因表达的肿瘤抗原; Activation of a growth factor receptor involves ligand binding, dimerization, and autophosphorylation, A truncated oncogenic receptor that lacks the ligand-binding region is constitutively active because it is not repressed by the N-terminal domain.; Translocations between chromosome 22 and chromosome 9 generate Philadephia chromosomes that synthesize bcl-abl fusion transcripts that are responsible for two types of leukemia.;Alteration Function of protein Tumor type Point mutation ERB B2 Growth factor receptor Breast carcinoma FMS CSF-1 receptor AML, myelodysplasia Ras GTP-binding protein Carcinomas and others p53 Tumor suppressor cell cycle control Many including bladder,