双语第十三章b淋巴细胞介导的体液免疫应答课件.pptVIP

第十三章 B淋巴细胞介导的体液免疫应答;第一节 B细胞对TD抗原的免疫应答;Antigen recognition of B cells;一、B细胞对TD抗原的识别;Double signals for B cells activation;;二、B细胞活化需要的信号;Clustering of BCR;B细胞活化的信号转导途径;Interaction between TH and B cells;T、B细胞相互作用;Proliferation and terminal differentiation of B cells ;三、B细胞的增殖和终末分化;Th细胞对B细胞的辅助作用发生于外周淋巴器官的T细胞区和生发中心。;专职APC（DC）捕捉、加工抗原;Development and differentiation of B cells in germinal centers;四、B细胞在生发中心的分化成熟;Somatic hypermutation;Affinity maturation;（一）体细胞高频突变和Ig亲和力成熟;Ig heavy-chain class switching;（二）Ig的类别转换;Formation of plasma cells;（三）浆细胞的形成;Memory B lymphocyte;（四）记忆性B细胞的产生;Antibody: neutralization, opsonization, complement activation and ADCC. Memory B cells; 五、B细胞的效应 抗体的效应 记忆性B细胞的效应;第二节 B细胞对TI抗原的免疫应答;TI antigen;At high concentrations TI-1 antigen acts with B cells as a mitogen. At low concentrations TI-1 antigen elicits an antigen-specific antibody response. ;TI-1抗原;TI-2 antigens are generally highly repetitive polymeric antigens. TI-2 antigens activate B cells through cross-linking of BCR molecules.;TI-2抗原诱导B细胞的激活; 多为细菌胞壁与荚膜多糖，具有高度重复的结构，仅能激活成熟的B细胞，应答的主要是B-1细胞。通过其高度重复的抗原表位使B细胞的mIg广泛交联而被激活，但过度交联会使成熟B细胞出现耐受。;Don’t require the presence of TH cells. Generate primarily IgM antibodies of low affinity. No somatic hypermutation, no affinity maturation, no Ig heavy-chain class switch and no memory B cells formation. ; 无Ig亲和力成熟 无Ig类别转换，只能产生IgM 无需Th细胞和巨噬细胞的参与 无记忆性B细胞形成,不能引起免疫记忆 ;第三节 体液免疫应答抗体产生的 一般规律;（一）初次应答;Primary response;Secondary response;（二）再次应答;characteristic