2009年Wnt_β-catenin signaling_ components, mechanisms, and diseases.pdfVIP

NIH Public Access Author Manuscript Dev Cell . Author manuscript; available in PMC 2010 April 29. N Published in final edited form as: I H Dev Cell . 2009 July ; 17(1): 9–26. doi:10.1016/j.devcel.2009.06.016. - P A A u Wnt/β-catenin signaling: components, mechanisms, and diseases t h o r 1 2 1 M Bryan T. MacDonald , Keiko Tamai , and Xi He a 1 n F. M. Kirby Neurobiology Center, Children’s Hospital Boston, Harvard Medical School, Boston, u MA 02115, USA s c r 2 i Department of Genetics, Case Western Reserve University, Cleveland, OH 44106, USA p t Abstract Signaling by the Wnt family of secreted glycolipoproteins via the transcription co-activator β-catenin controls embryonic development and adult homeostasis. Here we review recent progresses in this so-called canonical Wnt signaling pathway. We discuss Wnt ligands, agonists and antagonists and their interactions with Wnt receptors. We also dissect critical events that regulate β-catenin stability N from Wnt receptors to the cytoplasmic β-catenin destruction complex, and nuclear machinery that I H mediates β-catenin-dependent transcription. Finally we highlight some key aspects of Wnt/β-catenin - P signaling in human diseases including congenital malformations, cancer and osteoporosis and A potential therapeutic implications. A u t h o r Introduction M a Signaling by the Wnt family of secreted glycolipoproteins is