朱丹偏头痛ppt课件.pptVIP

Migraine;Famous people—Migraine; Outpatient and Emergency A severe headache at our clinics (60-90%) One of the four most devastating chronic diseases ( WHO).;Definition and Introduction ;Definition and Introduction ;Definition and Introduction;Ⅰ Cause and pathogenesis ;1 Certain foods 2 Genetics 3 Endocrine factor 4 vasomotor factor 5 spreading depression 6 Neurotransmitter; Certain foods tyramine（酪 ） containing cheeses, meat, such as hot dogs or bacon, with Nitrite（亚硝酸盐） preservatives, chocolate containing but not chocolate alone. ; Certain foods Food additives: monosodium glutamate Drugs : especially oral contraceptiveagents （避孕剂 ）; vasodilators （血管扩张剂） ; Certain foods Brights lights may also trigger or precipitate attacks. ;2. Genetics About 60% patients of migraine have family histories . Three genetic loci for familial hemiplegic（偏瘫） migraine have been identified . ; 3. Endocrine factor Gender: women men (2/3 to 3/4 of cases occur in women) Headache mostly occurs before or menacme（经期） in women , and the headache becomes reduction or stopping in pregnancy（怀孕） and after menopause（绝经）. ; 4. vasomotor factor Intracranial vasoconstriction（颅内血管收缩） and extracranial vasodilatation（颅外血管舒张） have long been held to be the respective causes of the aura（先兆） and headache phases of migraine. ; 5. spreading depression More recent studies of rCBF（cerebral blood flow） during migraine attacks have demonstrated a reduction in regional flow, which begins in the occipita region and then towards with 1 cm/s velocity during the aura phase. ; 6. Neurotransmitter Serotonin（五羟色胺） in platelets decreases and urinary serotonin（尿羟色胺） increases during the acute phase of a migraine attack . ; Ⅱ classification; Ⅲ Clinical features; 1. Classic mig