《肿瘤商学院》课件.ppt

肿瘤(Tumor, Neoplasma);第一节??? 肿瘤的概念和一般形态;一般形态（一）肉眼1 数目和大小：体积差别大。 2 形状：形态多种多样，与发生部位、组织起源、生长方式和肿瘤的良恶性有关。 3 颜色：灰白色，灰红色，少数有特定颜色。;Fig The normal appearance (upper left) of the cervix is shown grossly. Note the central cervical os and the smooth, glistening epithelial surface.Fungating, exophytic tumor (upper right) is seen on the cervix, typical for invasive squamous cell carcinoma.(lower right) Here is the uterus with tubes and ovaries resected at surgery. The uterus is opened to reveal a fungating tan mass. This is an endometrial carcinoma.;Small cell anaplastic (oat cell) carcinoma of the lung appears here in a smoker. Smokers who stop will diminish their risk for lung cancer, even after just a couple of years. Middle A large squamous cell carcinoma of the lung in a smoker is shown here. The incidence of both squamous cell carcinomas and small cell anaplastic carcinomas of lung is far greater in smokers than non-smokers. Right Emphysema, of the centrilobular type, with numerous enlarged air spaces as a result of the loss of lung tissue from smoking is demonstrated here grossly. Right normal lung.;（二）组织结构1 肿瘤的实质：肿瘤细胞的总称。根据实质进行分类，分期等。2 肿瘤的间质：由结缔组织和血管组成，有时还有淋巴管，支持营养肿瘤实质。;Fig This(left) lobulated tan-white mass involving the kidney of a child is a Wilms tumor. Clinically, it manifests most often as an abdominal mass. Over 90% are diagnosed in the first 6 years of life. About a fourth of cases are associated with hypertension. (right) The pelvis of the kidney is shown here with a transitional cell carcinoma. These carcinomas are more likely to occur in a smoker. These carcinomas also have a tendency to recur and to be multiple.;第二节??? 肿瘤的同型性和异型性;肿瘤细胞的异型性1 瘤细胞的多型性：形态不一。2 瘤细胞核的多型性：细胞核体积大，多形核。3 瘤细胞胞浆的改变：胞浆内核蛋白体增多，呈嗜碱性。分泌物不同而不完全一样。;Fig Upper , the appearance of a normal breast acinus is shown here. A layer of myoepithelial cells, some of which are slightly vacuolated, is seen just around the outside of the acinus. Middle, is atypical ductal epithelial hyperpla