抑制剂在心血管疾病中的应用课件.pptVIP

Use of Analgesics;Use of Analgesics;Use of non-aspirin NSAIDs in conjunction with aspirin for primary prophylaxis may increase the risk of first MI 22,000 male physicians on aspirin 325 mg QOD or placebo Aspirin use was associated with a 44% relative risk reduction of first MI Concomitant NSAID use for ? 60 days/yr associated with increased risk of first MI (RR 2.86; 95% CI 1.25-6.56) ;Possible Adverse Interactions between NSAIDs and ASA;Platelets in Hemostasis;Antiplatelet Action of Aspirin;The Balance of COX-1 and COX-2;The Balance of COX-1 and COX-2: A Simplified Model;Selective COX-2 Inhib