丙种球蛋白应用时间对川崎病患儿退热时间及冠脉损伤的影响分析.docVIP

丙种球蛋白应用时间对川崎病患儿退热时间及冠脉损伤的影响分析 　　【摘要】 目的：分析讨论丙种球蛋白应用时间对于川崎病患儿退热时间和冠脉损伤产生的影响。方法：选择2012年8月-2015年8月本院收治的80例川崎病患儿作为研究对象，根据丙种球蛋白应用时间将其分为常规组（发病后6～9 d应用）和晚期组（发病后≥10 d应用），每组40例，对两组患儿的冠状动脉病变发生情况以及退热时间等进行对比分析。结果：常规组患儿的临床症状消停时间均明显短于晚期组，差异均有统计学意义（P0.05）；常规组患儿的并发症发生情况及丙种球蛋白情况均明显优于晚期组，差异均有统计学意义（P0.05）。结论：就川崎病患儿来说，在发病后的6～9 d给予丙种球蛋白临床疗效最为明显，可明显降低不良反应发生率与冠状动脉病变发生率，提高患者生活质量和临床疗效，在临床中值得广泛推广与应用。 　　【关键词】 丙种球蛋白应用时间； 川崎病； 退热时间； 冠脉损伤 　　【Abstract】 Objective：To analyze and discuss the effect of application of Gamma Globulin in time for Kawasaki disease fever time and the effect of coronary artery injury.Method：80 children with Kawasaki disease in our hospital from August 2012 to August 2015 were selected as the research objects，according to the application time of Gamma Globulin，they were divided into the conventional group （6-9 d after onset） and late stage group （≥10 d after onset），40 cases in each group，the coronary artery disease occurrence and the cooling time of the two groups were analyzed.Result：The clinical symptoms persist time in conventional group were significantly lower than those in late stage group，the differences were statistically significant（P0.05）.The complications and Gamma Globul in conventional group were significantly better than those in late stage group，the differences were statistically significant（P0.05）.Conclusion：Children with Kawasaki disease，after the onset of 6-9 d to clinical curative effect of Gamma Globulin is most obvious，can significantly reduce the incidence of adverse reactions and the incidence of coronary artery disease，improve the quality of life and the clinical curative effect of children，worthy of promotion and application in clinical widely. 　　【Key words】 Gamma Globulin application time； Kawasaki； Pyretolysis time； Coronary artery injury 　　First-author’s address：Central People’s Hospital of Zhanjiang，Zhanjiang 524037，China 　　doi：10.3969/j.issn.1674-4985.2016.36.027 　　川崎病?称为皮肤黏膜淋巴结综合征，主要指的是病理特征为全身血管炎的急性出疹性发热性疾病，此疾病是易患宿主对于多种感染病原触发的免疫介导全身性血管