中科院细胞与分子免疫学课程chapter8课件.pptVIP

上堂课回顾：;T淋巴细胞的成熟：;2. 阴性选择： ;Chapter 8 Activation of T lymphocytes;How to activate the T cell? ;;Role of Costimulators in T Cell Activation;Role of CD40 in T cell activation;Signal Transduction by the TCR Complex;2. How is signal transduction triggered: by ligation of multiple antigen receptors and coreceptors. 3. What happened after signal transduction in cell: clustering of membrane receptors, tyrosine phosphorylation of several protein, and recruitment and activation of adapter proteins.;Major steps in signaling by the TCR;The formation of synapse was demonstrated by confocal microscopy.;2