主动脉夹层动脉瘤与主动脉真性动脉瘤的单核苷酸多态性研究 ppt课件.pptVIP

主动脉夹层动脉瘤与主动脉真性动脉瘤的单核苷酸多态性研究 Analysis of Candidate Genes by DNA Sequencing The α1 Chain of Type III Collagen Fibulin-2 Matrix Metallopeptidase 2 Tissue Inhibitor of Metallopeptidase 1 and 2 Cholesteryl Ester Transfer Protein Genetic Association Studies Using Known Polymorphisms in Candidate Genes Group I: Genes of the ECM—Structure and Remodeling of the Aorta Group II: Genes of the Cardiovascular System Group III: Genes of the Immune System Group IV: Genes of Signaling Pathways Group I: Genes of the ECM—Structure and Remodeling of the Aorta α1 Chain of Type III Collagen Fibrillin 1 Elastin ATP-binding Cassette Transporter, Subfamily C (CFTR/MRP), Member 6 Fibulin-5 Family of Matrix Metallopeptidases Tissue Inhibitor of Metallopeptidase 1, 2, and 3 Serine Peptidase Inhibitor, Clade A, Member 1 Serine Peptidase Inhibitor, Clade E, Member 1 Secreted Phosphoprotein 1 Xylosyltransferase 1 Cystatin C Group II: Genes of the Cardiovascular System Genes Involved in the Renin-Angiotensin-Aldosterone System Angiotensin 1 converting enzyme Angiotensinogen Angiotensinogen II receptor, type 1 Bradykinin receptor 2 Genes Involved in Lipid Metabolism Apolipoprotein B (including Ag(x) antigen) Apolipoprotein E Cholesteryl Ester Transfer Protein Coagulation Factor II (thrombin) and Coagulation Factor V (Proaccelerin, Labile Factor) Genes Involved in the Methionine Metabolism 5,10-Methylenetetrahydrofolate reductase Methylenetetrahydrofolate dehydrogenase 1 5-Methyltetrahydrofolate-homocysteine methyltransferase 5-Methyltetrahydrofolate-homocysteine methyltransferase reductase Thymidylate synthetase Adenosylhomocysteinase Folate hydrolase 1 Endothelial Constitutive Nitric Oxide Synthase Prostaglandin-endoperoxide Synthase 2 Haptoglobin Blood Groups Genome-Wide Association Studies A SNP (rs763518) located on chromosome 3p12.3, a region near contactin-3 (CNTN3) gene, was associated with AAA The CNTN3 protein is a lipid-anchored cell adhesion mol