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CP887679 Jaffe,AS ma 10-29-1999 * CP1189452-27 ED Probability of CHF Recorded P0.0001 from clinical judgment to combined McCullough PA et al: Circulation 106:416, 2002 Diagnostic accuracy (%) Clinicaljudgment BNP Combined 70 72 74 76 78 80 82 74.0 81.2 81.5 n=1,538 BNP Study Primary End Point n=1,586; ?50% CHF; 56% male;64±17 yo; 41% COPD; ?30% Hx CHF CP1189452-28 BNP(pg/mL) Sens Spec PPV NPV 50 97 62 71 95 100 90 76 79 89 150 85 83 83 85 AUC = 0.91 Breathing Not Proper (BNP)Multicenter Trial AJC 95, April 15, 2005 Optimal cut-point Sens Spec PPV NPV Accuracy (%) (%) (%)