低氧与肿瘤多药耐药ppt课件.pptVIP

低氧与肿瘤多药耐药;Content;Part I;Reason of Death;Mechanism of Multidrug Resistance;;Cellular Factors of Cause MDR;Focus on;Research Field;HIF-1a Structure;Hypoxia and HIF-1a;HiF-1a and Apoptosis;Conclusion of Part I;Part Ⅱ;丁震宇,梁后杰 免疫学杂志 2008;Min Liu, et al, JBC,2007 online;JNK down-regulates MDR1 expression in normoxia and up-regulates MDR1 expression in hypoxia;Xianrang, et al Cancer Chemother Pharmacol,2006 online ;;Part Ⅲ;Roy Vergis, Lancet Oncol. 2008 online;HIF-1 alpha score 4 (B) HIF-1 alpha score 1 (C) HIF-1 alpha score 0 ;Kourti, In