CD133Ki―67在胃癌表达及临床病理意义.doc

CD133Ki―67在胃癌表达及临床病理意义 　　[摘要] 目的 探讨CD133、Ki-67在胃癌的表达及临床病理意义。 方法 随机选取本院2008年5月～2012年9月的首发胃癌患者300例，所有患者进行免疫组化检测，对胃癌组织中CD133、Ki-67的阳性表达及病理特征的关系进行分析，观察患者的术后生存时间。 结果 300例胃癌中，CD133阳性的患者184例，阳性率为61.33%。Ki-67阳性的患者179例，阳性率为59.67%。CD133和Ki-67的表达随着肿瘤增大、分化降低、浸润加深、淋巴结转移数目增多、TNM分期递增，出现腹腔及远处转移等因素而逐渐增高（P0.05）。Cox多因素术后生存分析结果显示， 胃癌术后生存时间的独立预后因子为患者年龄、 肿瘤大小、组织学类型、 CD133、Ki-67、腹腔及远处转移。 结论 CD133和Ki-67联合检测可作为胃癌的临床评价肿瘤生物学行为及判断预后的有用指标之一。 　　[关键词] 胃癌；CD133；Ki-67；表达；临床病理 　　[中图分类号] R735.2 [文献标识码] B [文章编号] 2095-0616（2015）20-157-04 　　The expression of CD133 and Ki-67 in gastric cancer and its clinical significance 　　LIU Na 　　Department of Pathology， Yilan County Peoples Hospital， Yilan 154800， China 　　[Abstract] Objective To investigate the The expression of CD133 and Ki-67 in gastric cancer and its clinical significance. Methods 86 cases of patients with diabetic retinopathy from May 2008- September 2012 were selected as the observation group， 98 cases of diabetic patients without retinopathy were selected as the control group， 80 cases of healthy people were selected as normal group . All subjects were resting fasting urine microalbumin（UmAlb） and glycosylated hemoglobin （HbA1C）， using ABC- enzyme-linked immunosorbent assay and analysis of peripheral blood IGF-1 and TGF-β1 expression and among the three groups level situation. Results In 300 cases of gastric cancer， 184 cases of CD133 positive patients， positive rate of Ki-67was 61.33%. Positive patients in 179 cases， the positive rate was 59.67%. The expression of CD133 and Ki-67 increased with the increase of tumor， differentiation， invasion， lymph node metastasis， TNM stage， P0.05. Cox， and survival analysis showed that the independent prognostic factors were age， tumor size， histological type， Ki-67， CD133， abdominal and distant metastasis. Conclusion The combined detection of CD133 and Ki-67 can be used as a useful index for clinical evaluation of tumor biological behavior and prognosis of gastric cancer. 　　[Key words] Gastric can