CD15s和CD138在胃癌中表达及相关性研究.docVIP

CD15s和CD138在胃癌中表达及相关性研究 　　[摘要]目的：探讨CD15s和CD138基因蛋白在胃癌中的表达及意义。方法：应用免疫组织化学技术，对17例早期胃癌和78例进展期胃癌组织进行CD15s和CD138蛋白的检测，并结合肿瘤的病理生物学行为和临床随访资料进行分析。结果：胃癌中CD15s和CD138蛋白表达阳性率分别为86.3%和15.8%。进展期胃癌CD15s表达阳性率明显高于早期胃癌(P0.05)，而CD138阳性表达率则明显低于早期胃癌(P0.05)；CD15s高表达和CD138低表达与胃癌转移和预后有关。结论：CD15s和CD138表达与胃癌转移和患者生存期密切相关，检测CD15s和CD138的表达可作为判断胃癌预后的参考指标。 　　[关键词]胃癌；CD15s；CD138；预后 　　[中图分类号]R735 [文献标识码]B[文章编号]1673-7210（2007）08（c）-100-02 　　 　　Study on expression of CD15s and CD138 in stomach carcinoma and their relationships 　　ZHU Xi-qin,MIAO Jian-jun,JIA Guo-hong,ZHANG Jin-jiang,SHANG Pei-zhong,GU Hua-ping 　　（Department of General Surgery,the 251 Hospital of PLA,Zhangjiakou 075000，China） 　　[Abstract] Objective：To investigate the expression of CD15s and CD138 gene protein in stomach carcinoma and its clinical significance.Methods：Immunohistochemistry was used to detect the expression of CD15s and CD138 protein in 17 cases of early stage and 78 cases advanced carcinoma of stomach. The pathobiologic behavior and follow-up was done. Results：The positive rates of CD15s and CD138 were 86.3% and 15.8% respectively in primary stomach carcinoma. The positive rate of CD15s in advanced carcinoma of stomach was higher than that in early stage stomach carcinoma. The positive rate of CD138 in advanced carcinoma of stomach was lower than that in early stage stomach carcinoma. The high level expression of CD15s and the low level expression of CD138 were positively correlated with metastasis and prognosis of patients.Conclusion：The expression of CD15s and CD138 was closely related to the potential of metastasis and survival rate in stomach carcinoma. CD15s and CD138 may be prognostic indicators in stomach carcinoma. 　　[Key words]Stomach neoplasms；CD15s；CD138；Prognosis 　　 　　我们采用免疫组织化学方法，探讨CD15s和CD138基因蛋白的表达与胃癌临床病理生物学行为和预后的关系，以及两种基因蛋白表达之间的相关性，为判断胃癌患者的预后提供参考。 　　 　　1 资料和方法 　　 　　1.1资料 　　取解放军251医院1990年2月～2003年2月手术切除的胃癌标本95例，按胃癌的临床病理分期方法进行病理诊断[1]。高分化癌18例，中低分化癌77例；有浆膜浸润者40例，无浆膜浸润者55例；有淋巴结转移者68例，无淋巴结转移者27例