CD64PCThs―CRP联合检测对新生儿败血症诊断临床意义.docVIP

CD64PCThs―CRP联合检测对新生儿败血症诊断临床意义 　　【摘要】 目的：探讨CD64、PCT、hs-CRP联合检测对新生儿败血症诊断的临床意义。方法：选取2013年5月-2014年10月本院收治的70例新生儿败血症患儿作为观察组，选择同一时期70例非感染患儿作为对照组，对两组患儿临床资料进行回顾性分析。所有患儿均于入院后6 h分别检测全血超敏C反应蛋白（hs-CRP）、嗜中性粒细胞CD64、血浆降钙素原（PCT）3项指标，治疗1周后选择观察组中临床好转的患儿作为恢复组，检测恢复组患儿的PCT、hs-CRP、CD64 3项指标，比较不同检测指标的诊断价值。结果：观察组CD64、PCT、hs-CRP 3项指标均显著高于恢复组及对照组，比较差异均有统计学意义（P0.05）；联合检测的特异性、敏感性、阳性预测值、阴性预测值以及约登指数均明显高于单独或PCT联合hs-CRP检测，比较差异均有统计学意义（P0.05）。结论：CD64、PCT、hs-CRP联合检测应用于新生儿败血症诊断中具有较高的诊断价值，能够有效提高败血症患儿早期诊断的准确性，便于为败血症的早期治疗提供重要的参考依据，值得在临床上推广应用。 　　【关键词】 CD64； PCT； hs-CRP； 新生儿； 败血症； 诊断意义 　　Clinical Significance of CD64，PCT and hs-CRP Joint Detection in the Diagnosis of Neonatal Sepsis/LEI Xue-wei.//Medical Innovation of China，2015，12（34）：029-031 　　【Abstract】 Objective：To study the clinical significance of CD64，PCT，hs-CRP joint detection in the diagnosis of neonatal sepsis.Method：70 cases of neonatal sepsis patients in our hospital from May 2013 to October 2014 were selected as the observation group.70 non-infective patients in our hospital were selected as the control group at the same time.The clinical data of the two groups were retrospectively analyzed.The high sensitivity C-reactive protein（hs-CRP），the neutrophil CD64 and the plasma procalcitonin（PCT） of the patients were detected 6 hours after admission.After one week of treatment，patients with clinical improvement in the observation group were selected as the recovery group.The CD64，PCT and hs-CRP of the recovery group were detected.The diagnosis values of different indicators were compared.Result：The CD64，PCT and hs-CRP of the observation were higher than those of the control group and those of the recovery group，the differences were statistically significant（P0.05）.The specificity，sensitivity，positive predictive value，negative predictive value and Youden index of the joint detection were higher than those of the single detection and PCT combined with hs-CRP detection，the differences were statistically significant（P0.05）.Conclusion：The joint det