铜离子特异性荧光探针知识.pdf

Tetrahedron 66 (2010) 3695–3701 Contents lists available at ScienceDirect Tetrahedron journal homepage: www.el /locate/tet Squaraine-based colorimetric and fluorescent sensors for Cu2þ-specific detection and fluorescence imaging in living cells Weida Wang a, Afu Fu b, Jingsong You a,b, Ge Gao a, Jingbo Lan a, *, Lijuan Chen b, * a Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu 610064, PR China b State Key laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Keyuan Road 4, Gaopeng Street, Chengdu 610041, PR China a r t i c l e i n f o a b s t r a c t Article history: New squaraine-based chemosensors SQ1 and SQ2 functionalized with 2-picolyl units were first syn- Received 4 February 2010 thesized and used as highly selective and sensitive colorimetric and fluorometric dual-channel sensors Received in revised form 18 March 2010 for Cu2þ-specific recognition in aqueous systems. Among a series of individual metal ions, only Cu2þ Accepted 19 March 2010 could result in dramatic color changes. We also evaluated their capability of biological applications and Available online 27 March 2010 2þ found that SQ2 could be successfully employed as a Cu -selective probe in the fluorescence imaging of