中国医学创新目次右美托咪定在静吸复合麻醉下对食管癌根治术患者神经功能及认知功能影响.docVIP

中国医学创新目次右美托咪定在静吸复合麻醉下对食管癌根治术患者神经功能及认知功能的影响 　　【摘要】 目的：探?静吸复合麻醉联合右美托咪定对接受食管癌根治术患者的神经功能及认知功能的影响。方法：选取2015年2月-2017年9月本院收治的确诊为食管癌并需进行手术治疗的患者88例，按照随机数字表法将其分为研究组和对照组，各44例。对照组采用静吸复合麻醉的麻醉方法，研究组在对照组基础上联合右美托咪定。比较两组麻醉诱导时间、手术时间、术后苏醒时间及气管拔除时间；比较两组麻醉前及术后1 d内的简易精神状态量表（MMSE）评分及完成连线试验（TMT）所用时间；比较两组手术前后的神经元特异性烯醇化酶（NSE）、血清神经生长因子（NGF）、脑源性神经营养因子（BDNF）；比较两组的满意度情况。结果：研究组麻醉诱导时间、手术时间、术后苏醒时间及气管拔除时间均明显短于对照组（P0.05）；术后，研究组NGF、BDNF、MMSE评分均高于对照组，NSE、完成TMT所用时间均明显低于对照组，差异均有统计学意义（P0.05）。研究组治疗总满意度为84.1%，明显高于对照组的56.8%，差异有统计学意义（P0.05）。结论：在静吸复合麻醉的基础上联合右美托咪定对食管癌患者进行术前麻醉，能够优化麻醉效果，减少麻醉药物对患者神经功以及认知功能的损伤程度，值得临床上广泛推荐使用。 　　【关键词】 右美托咪定； 静吸复合麻醉； 食管癌根治术； 神经功能； 认知功能 　　Effect of Intravenous Inhalational Anesthesia Combined with Dexmedetomidine on Neurological Function and Cognitive Function of Patients Undergoing Radical Resection of Esophageal Carcinoma under Intravenous Inhalational Anesthesia/GUAN Jiang.//Medical Innovation of China，2018，15（03）：054-057 　　【Abstract】 Objective：To investigate the effects of intravenous inhalational anesthesia combined with Dexmedetomidine on the neurologic function and cognitive function of patients undergoing radical resection of esophageal carcinoma.Method：A total of 88 patients who were diagnosed with esophageal carcinoma and needed surgical treatment in our hospital from February 2015 to September 2017 were selected，according to the random number table method，they were divided into study group and control group，44 cases in each group.The control group was anesthetized by intravenous inhalational anesthesia，and study group was combined with Dexmedetomidine on the basis of control group.The anesthesia induction time，operation time，recovery time after the operation and extraction time of the trachea were compared between two groups，mini-mental state examination（MMSE） score and the time used to complete the connection test（TMT） before and after anesthesia 1 d of two groups were compared，the neuron specific enolase（NSE），serum nerve growth factor（NGF） and brain derived neurotroph