实验诊断学-血栓止血学原理及实验诊断.pptVIP

* Within seconds after vascular injury platelets accumulate and adhere to the damaged vessel wall where they become activated, triggering the release of prothrombotic factors such as thromboxane A2 and ADP through platelet dense granules. This release of activators propagates platelet activation, which leads to subsequent aggregation. This activation of platelets represents a continuing assault on lesions throughout the vasculature. The key to chronic control of platelet aggregation is to manage this ongoing rapid onset of platelet ACTIVATION. ? References: ? Gibbons, J.M. 2004. Platelet