探讨脉搏波速度和冠状动脉粥样硬化的关系.doc

探讨脉搏波速度与冠状动脉粥样硬化的关系 王连连 程育博 （北京燕化医院心内科，北京市房山区，102500） [关键词] 脉搏波速度；冠状动脉粥样硬化；冠状动脉造影 [摘要] 目的 探讨脉搏波速度与冠状动脉粥样硬化程度的关系。方法 本文选择行冠状动脉造影治疗的患者100例，进行脉搏波速度测定，与冠状动脉造影相对比。结果 冠脉造影结果与PWV：冠脉造影正常组（36例）PWV(m/s)：11.29±1.37，冠脉造影异常组（64例）PWV(m/s): 14.99±1.02,其中冠脉单支病变（13例）PWV(m/s)：12.42±0.96，冠脉双支病变（16例）PWV(m/s)：14.97±0.80，冠脉多支病变（35例）PWV(m/s)：17.59±1.04。结论冠造异常组较冠脉正常组PWV显著增高( P 0. 01) ,脉搏波传导速度与冠脉病变的支数有明显相关行，脉搏波传导速度越快，冠脉病变支数越多。 The Relationship Between Pulse Wave Velocity and Coronary Atherosclerosis Wang Lian-lian,Cheng Yu-bo (Cardiovascular Department ,Yanhua Hospital of Beijing ,Fangshan 102500 ,China) [KEY WORDS] Pulse Wave Velocity(PWV);Coronary Atherosclerosis; Coronary Arteriongraphy(CAG) [ABSTRACT] Objective To explore the relationship between pulse wave velocity (PWV) and coronary atherosclerosis branch of coronary arteriongraphy (CAG). Methods To totally 100 patients of CAG were recorded by an automatic pulse wave velocity measurement system and these was comparison between the patients of PWV and those of CAG. Result There was significantly different in PWV between in 36 patients of normal CAG 11.29±1.3PWV cm/s and 64 patients of narrow CAG 14.99±1.02PWV cm/s (p0.05).According to narrow branch of CAG 36 patients of 1 branch was 12.42±0.96 PWV cm/s (p0.05). 16 patients of 2 branches was 14.97±0.80 PWV cm/s (p0.02). 35 patients of more branches was 17.59±1.04 PWV cm/s (p0.01). Coclusion There was significantly relationship in PWV between the patients of normal CAG and those of narrow CAG. The more narrow branch of coronary artery disease, the higher PWV of patients. 冠心病严重威胁人类健康，且发病率逐年增高。动脉僵硬度对冠心病的发生、发展起着重要的作用，研究表明动脉僵硬度的改变早于结构改变［1、2］，是各种心血管事件发生发展的基础。作为评价动脉僵硬度的一个指标，脉搏波传导速度（PWV）的作用正日益受到重视。本文通过对100例病人进行冠状动脉造影和PWV测定，来探讨脉搏波速度（PWV）与冠状动脉粥样硬化的关系，为冠心病的早期防治提供依据。 一、对象与方法：2007年7月至12月北京燕化医院心内科100例住院病人，根据冠脉造影结果分组，正常组36例，其中男性26例，女性10例，异常组64例，其中男性52例，女性12例，正常组年龄58. 42 ±8. 79 ，异常组年龄63. 08 ±7. 48，两组间的体重指数，血糖，血脂无明显差异（表1）。危险因素，吸烟史：正常组44％，异常组55％，冠心病家族史：正常组45％，异常组58％，高血压：正常组76％，异常组90%，糖尿病：正常组30％，异常组35%，高