苦瓜提取物对高脂肪喂食诱导的肥胖及胰岛抵抗C57BL_6j小鼠保护作用研究_英文.pdfVIP

54 6 ( ) Vol. 54 No. 6 第 卷 第 期 中山大学学报 自然科学版 2015 年 11 月 ACTA SCIENTIAＲUM NATUＲALIUM UNIVEＲSITATIS SUNYATSENI Nov. 2015 DOI :10. 13471 /j. cnki. acta. snus. 2015. 06. 002 Momordica charantia Extract Protects C57BL /6j Mice from High-Fat-Diet-Induced Obesity and * Insulin Ｒesistance 1 2 1 3 ，4 WANG Ｒikang ，ZHAO Tingting ，SUN Yongbing ，CHEN Heru (1． National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine， Jiangxi University of Traditional Chinese Medicine ，Nanchang 330006 ，China ; 2． Department of Pharmacy ，Puyang Maternaity and Child Care Hospital ，Kaizhou south road ， Puyang 457000 ，China ; 3． Institute of Traditional Chinese Medicine and Natural Products ，College of Pharmacy ， Jinan University ，Guangzhou 510632 ，China ; 4． Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Ｒesearch ，Guangzhou 510632 ，China) Abstract :In order to investigate the protective effects of Momordica charantia extract (MCE)on obesity and insu- lin resistance ，C57BL /6j mice fed in a high-fat diet (HFD)were used as animal model． Obese mouse model was successfully made after 2-week HFD induction． The mice were then randomly divided into normal control ，model control ，MCE dose of 13. 5 ，27. 0 ，and 54. 0 g /kg treated groups． Mice in normal and model control groups were treate