参麦注射液联合生长抑素对急性胰腺炎患者血清TNFαIL6及IL10影响.doc

参麦注射液联合生长抑素对急性胰腺炎患者血清TNFαIL6及IL10影响 　　[摘要] 目的 探讨分析参麦注射液联合生长抑素对急性胰腺炎患者血清肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）及白细胞介素-10（IL-10）的影响。 方法 选择2011年1月～2013年9月在衢州市人民医院接受治疗的重症急性胰腺炎患者90例，随机分成两组。对照组45例患者单纯给予西药治疗。观察组45例患者在对照组治疗的基础上，增加参麦注射液及生长抑素治疗。观察两组8 d内血淀粉酶以及白细胞达到正常范围的时间、腹痛症状改善与住院时间。 结果 观察组总有效率（95.6%）高于对照组（80.0%），差异有统计学意义（P ＜ 0.05）。观察组患者血淀粉酶以及白细胞达到正常范围的时间、腹痛症状改善时间与住院天数方面显著短于对照组，差异有高度统计学意义（P ＜ 0.01）。治疗后，观察组血清TNF-α、IL-6水平为（168.66±24.64）、（15.45±5.36）ng/L，均低于对照组血清TNF-α、IL-6水平[（206.32±20.49）、（21.28±7.31）ng/L]，差异有高度统计学意义（P ＜ 0.01）。治疗后，观察组血清IL-10水平为（99.54±16.11）ng/L，高于对照组血清IL-10水平[（69.42±15.57）ng/L]，差异有高度统计学意义（P ＜ 0.01）。 结论 参麦注射液联合生长抑素治疗重症急性胰腺炎效果显著，可以明显改善患者血清TNF-α、IL-6及IL-10水平。 　　[关键词] 重症急性胰腺炎；参麦注射液；生长抑素；肿瘤坏死因子-α；白细胞介素-6；白细胞介素-10 　　[中图分类号] R576[文献标识码] A[文章编号] 1673-7210（2014）05（c）-0068-04 　　 　　Effect of Shenmai Injection combined with somatostatin on serum levels of TNF-α, IL-6 and IL-10 in patients with acute pancreatitis 　　YE Quanzhong CHENG Jin LIU Longqun 　　Department of Gastroenterology, the Peoples Hospital of Quzhou City, Zhejiang Province, Quzhou 324000, China 　　[Abstract] Objective To investigate and analyze the effects of Shenmai Injection combined with somatostatin on serum levels of tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6) and interleukin-10 (IL-10) in patients with acute pancreatitis. Methods 90 cases of patients with severe acute pancreatitis treated in the Peoples Hospital of QuzhouCity from January 2011 to September 2013 were randomly divided into two groups. 45 patients in the control group were treated with western medicine. 45 patients in the observation group were added with Shenmai Injection and somatostatin treatment on basis of control group. The time of serum amylase and white blood cells to normal range, time of abdominal pain symptom improvement and days of hospitalization were observed. Results The total efficiency of the observation group was 95.6%, which was higher than 80.0% of control group, the difference was statistically significant (