参麦注射液联合曲美他嗪治疗冠心病心绞痛临床疗效评价.doc

参麦注射液联合曲美他嗪治疗冠心病心绞痛临床疗效评价 　　[摘要] 目的 评价参麦注射液联合曲美他嗪治疗冠心病心绞痛的临床疗效。 方法 选择2014年1月～2015年1月在本院住院治疗的100例冠心病心绞痛患者作为研究对象，采用随机数字表法分为联合组与对照组，每组各50例；两组均予抗血小板聚集药、调脂药、ACEI、β受体阻滞剂、利尿剂、硝酸酯类及洋地黄类等常规治疗。对照组加用曲美他嗪20 mg，每天3次；联合组在对照组基础上加用参麦注射液20 mL静脉滴注，每天1次。14～21天为1疗程，两组治疗1个疗程后评定临床疗效及心电图数据。并对两组患者治疗前后NST和ΣST的变化情况、每周心绞痛发作次数及持续时间进行统计学分析。 结果 联合组治疗后总有效率96.0%，显著高于对照组治疗后总有效率78.0%，两组的临床疗效对比分析显示，联合组的疗效优于对照组，差异具有统计学意义（P0.05）。两组心电图数据评价对比分析显示，联合组治疗后总有效率94.0%，显著高于对照组治疗后总有效率76.0%，联合组的疗效优于对照组，差异具有统计学意义（P0.05）。联合组治疗后NST、ΣST较治疗前及对照组显著降低，且联合组治疗后每周心绞痛发作次数及持续时间较治疗前及对照组显著降低，差异具有统计学意义（P0.05）。 结论 参麦注射液联合曲美他嗪治疗冠心病心绞痛疗效确切，值得在临床推广应用。 　　[关键词] 冠心病心绞痛；参麦注射液；曲美他嗪；心电图 　　[中图分类号] R541.4 [文献标识码] B [文章编号] 1673-9701（2016）06-0111-04 　　Clinical effect evaluation of shenmai injection combined with trimetazidine in treatment of coronary heart disease angina 　　LIU Shankuan1 ZHAO Qifeng2 　　1.Department of Cardiology， Zhejiang Putuo Hospital， Zhoushan 316100， China； 2.Department of Thoracic Surgery， Wenzhou Medical University Second Affiliated Hospital， Wenzhou 325000， China 　　[Abstract] Objective To evaluate the clinical effects of Shenmai injection combined with trimetazidine in treatment of coronary heart disease angina. Methods 100 patients with coronary heart disease angina treated in our hospital from January 2014 to January 2015 were selected and randomly divided into the combination group and the control group. Patients in both groups were treated by routine medication including anti-platelet aggregation drugs， lipid regulation drugs， ACEI， β receptor blockers， diuretics， nitrates， and digitalis. Patients in the control group were additionally treated by trimetazidine 20 mg， tid； and patients in the combination group were given trimetazidine 20 mg， tid， plus Shenmai injection 20 mL， iv gtt， qd. The clinical effects and ECG effects in two groups were evaluated after one course of treatment（14-21 days）. The NST and ST changes， and weekly frequency and duration of angina of patients in two groups before and after trea