传染病学教学课件cholera双语.pptx

Cholera; Emphases!;Conception;Etiology ;Resistance: sensitive to low PH and die rapidly in solutions below PH 6 quite tolerate of alkaline conditions Enrichment media 1.Alkaline peptone water at pH 8.6 2.Monsurs taurocholate tellurite peptone water at pH 9.2;Plating media; Classification 1. O1 serogroup: classified into 3 serotypes: Ogawa containing antigen A and B Inaba containing antigen A and C Hikojema containing antigen A、B and C 2 biotypes: classic 19 century EI Tor 20 century 2. Atypical O1 serogroup 3. non-O1 serogroups（O139 ） There are numerous serogroups of V. cholerae ,they have common flagellar antigen and distinguished by the somatic classic .Only O1 and O139 are associated with cholera. ; Cholera toxin (CT) : key factor Endotoxin Neurotoxin Hemagglutinin Toxin coregulated pilus (Tcp);Cholera Toxin;Pathway continued;Toxin Pathway Cartoon; Epidemiology;Epidemiology ;V.cholerae;Clinical manifestations;Dehydration stage： severe dehydration anxious, relaxed shin, oliguria, weak and rapid pulse, decreased blood pressure, imbalance of electrolyte metabolic acidosis Recover stage： warm surface, strong pulse, increased blood pressure； 1/3 patients have higher tempreature 38~39℃(absorption fever) ;A person with severe dehydration due to cholera - note the sunken eyes and decreased skin turgor which produces wrinkled hands. ;———————————————————————————— manifestations mild moderate severe ———————————————————————————— Numbers of diarrhea 10 10~20 20