呼吸功能及血清细胞因子影响.docVIP

呼吸功能及血清细胞因子影响 　　[摘要] 目的 观察常规疗法加乙酰半胱氨酸口服对慢性阻塞性肺疾病（COPD）患者肺通气功能及血清细胞因子IL-8、TNF-a、IL-10改变的影响。 方法 将COPD急性加重期的85例患者随机分为A、B两组。A组（治疗组）45例，在常规治疗基础上加用乙酰半胱氨酸胶囊400 mg口服，每日3次，连用10 d。B组（对照组）40例，仅常规治疗，不加用乙酰半胱氨酸胶囊口服。治疗前后观察肺通气功能、血气分析及血清细胞因子（IL-8、TNF-a、IL-10）的改变。 结果 A、B两组患者经治疗后肺通气功能及动脉血气分析指标均有好转，血清IL-8、TNF-a、IL-10的表达亦均有改善，并且A组优于B组（P0.05）。 结论 乙酰半胱氨酸可有效改善COPD患者呼吸功能，改善血清IL-8、TNF-a、IL-10的表达。 　　[关键词] 慢性阻塞性肺疾病；乙酰半胱氨酸；肺功能；肿瘤坏死因子；白细胞介素8；白细胞介素10 　　[中图分类号] R563 [文献标识码] A [文章编号] 2095-0616（2013）13-42-02 　　Effects of acetylcysteine on chronic obstructive pulmonary disease patients respiratory function and serum cytokines 　　LIU Xiaohui1 JIN Yan1 DENG Shuxian1 ZHU Shuangqing2 　　1.Fourth Hospital of Jinlin University， Changchun 130011，China；2.Health and Epidemic Prevention Station of FAW Division， Changchun 130011，China 　　[Abstract] Objective To observe changes and effects of conventional treatment plus oral Acetylcysteine on COPD patients pulmonary ventilation function and serum cytokines IL-8， TNF-a， and IL-10. Methods Eighty-five patients with acute exacerbation of COPD were randomly divided into Group A and Group B. Forty-five patients in group A which were treated with acetylcysteine， besides conventional treatments， also were taken acetylcysteine pills （400 mg） tid for 10 days. At the same time， forty patients in group B for comparison only were received conventional treatment without any acetylcysteine pills. The changes of lung function， blood gas analysis and serum cytokines IL-8， TNF-a， and IL-10 before and after the treatment were observed. Results Pulmonary ventilation function， arterial blood gas and serum cytokines IL-8， TNF-a and IL-10 were improved in all patients from both groups A and B. And group A is even better than group B （P0.05）. Conclusion Acetylcysteine can effectively improve COPD patients respiratory function and indicators of serum IL-8， TNF-a and IL10. 　　[Key words] COPD； Acetylcysteine； Lung function； TNF-a； IL-8； IL-10 　　慢性阻塞性肺疾病（COPD）是一种常见的慢性呼吸系疾病，患病人数多，病死