基于免疫功能重度心理应激孕产妇护理评价.docVIP

基于免疫功能重度心理应激孕产妇护理评价 　　【摘要】 目的：从CD4+CD25+调节性T细胞（Treg）功能角度评价心理护理干预对重度心理应激孕产妇的作用。方法：选取2012年1月-2014年6月本院产科收治的60例重度心理应激孕产妇作为研究对象，按照住院先后顺序随机分为对照组和观察组，每组30例。对照组给予常规护理，观察组在对照组基础上给予心理护理，另择同期收治的60例非心理应激孕产妇作为阴性对照。采用流式细胞术检测两组外周血CD4+CD25+ Treg、胞内转化生长因子β1（TGF-β1）及白介素10（IL-10）含量，采用焦虑自评量表（SAS）和抑郁自评量表（SDS）对护理前后两组孕产妇焦虑和抑郁进行评分，观察两组妊娠结局。结果：与非心理应激孕产妇比较，重度心理应激孕产妇的SAS和SDS评分明显升高，而Treg、TGF-β1及IL-10含量降低。护理后，观察组SAS和SDS评分低于护理前，Treg、TGF-β1及IL-10含量高于护理前，且观察组优于对照组，比较差异均有统计学意义（P0.05）；Pearson相关性分析显示Treg、TGF-β1及IL-10均与SAS及SDS呈显著负相关性（P0.05）；观察组顺产率83.33%，高于对照组的70.00%，比较差异有统计学意义（P0.05）。结论：重度心理应激孕产妇Treg及其细胞因子表达含量明显降低，并且与心理应激程度呈显著负相关性；心理护理可以显著改善心理应激程度及上述免疫功能的改变，提示护理对该类患者的免疫功能有显著改善作用。 　　【关键词】 孕产妇； 心理应激； 心理护理； CD4+CD25+调节性T细胞； 细胞因子 　　Nursing Evaluation on the Pregnant Woman with Severe Psychological Stress via the Immune Function/ZHONG Ying.//Medical Innovation of China，2016，13（20）：074-077 　　【Abstract】 Objective：To evaluate the nursing effect on the pregnant woman with severe psychological stress via the immune function of CD4+CD25+ regulatory T cells.Method：From January 2012 to June 2014，60 cases of severe psychological stress pregnant women in our hospital were selected as the research objects，they were randomly divided into the control group and observation group，each group had 30 cases.The control group was given routine care，the observation group was given psychological care on basis of the control group，and the other 60 cases at the same period were treated as negative control.Two groups of peripheral blood CD4+CD25+ regulatory T cells （Treg），intracellular transformation growth factorβ1 （TGF-β1） and interleukin 10 （IL-10） content were detected by flow cytometry，two groups of anxiety and depression situation were evaluated by self rating Anxiety Scale （SAS） and self rating depression scale （SDS） before and after nursing.Two groups of pregnancy outcome were observed.Result：The SAS and SDS scores of the severe psychological stress pregnant women were significantly higher than the non psychological