腹透中心设置、管理及质量持续改进-江西幻灯片.pptVIP

研究目的 肠道病源菌进入腹腔的路径及可能机制 致腹膜炎E.coli菌株的生物学表型特征 腹腔天然免疫状态及与腹膜炎的关系 自噬在腹透相关腹膜炎的作用及机制 腹腔免疫功能研究 病源菌研究 腹腔天然免疫状态 E.coli种系发育群、血清型、毒力因子特征 PD对肠道E.coli菌丛变异的影响 确定易感类型 减少腹膜炎发生，改善腹膜炎预后 腹透时间对患者腹腔免疫状态影响 制定防治策略 确定易感因素 提高腹透患者技术存活率 技术路线 初步研究结果 Phenotypic Alteration of Peritoneal Macrophages in continuous Ambulatory Peritoneal Dialysis Patients. A Reduction of Alternatively Activated Macrophages in the Dialysate of Peritoneal Dialysis Patients with Peritonitis Autophagy phenomenon occurred in both PMC and Macrophage in Patients with CAPD-related Peritonitis HSP72 prevents LPS-induced apoptosis through enhancement of autophagy in human mesothelial cells 临床研究重点 Preservation of Peritoneal function Preservation of residual renal function Bio-maker for the early diagnosis of UF The mechanism of Peritonitis PD Satellite training Center in Guangdong 临床研究方面的主要成绩 1. Set up PD satellite centers in Guangdong （ Perit Dial Int. 2011,31: in press） 2. Run a successful PD program in Southern China (submitted to Perit Dial Int ) 3. Glucose-based peritoneal dialysis fluids ……Clin Vaccine Immunol. 2010, 17: 757-63 4. No need for an expiry date in chronic PD patients . Int Urol Nephrol. 2010; 42:241-2 5. Aeromonas salmonicida peritonitis …. ..Perit Dial Int. 2008. 28:316-7. 6. Effect of social support on psychological status in CAPD patients. J Psychosom Res. 2008; 65:157-64. 主要在研项目 The pathogenesis of peritoneal dialysis-related Escherichia coli peritonitis Biomarkers for early diagnosis of ultrafiltration failure in peritoneal dialysis patients. The mechanism of autophagy in peritoneal mesothelial cells and its role in bacterial defense. Effect of ACEI/ARB therapy on peritoneal membrane function in peritoneal dialysis patients. Advancing the quality of peritoneal dialysis by setting up PD satellite center. Effect of diuretic on volume control and residual renal function in peritoneal dialysis patients. 余学清教授作为中国大陆代表应邀作大会学术报告 9篇学术论文被选为大会宣读(占大会口头报告的1/10)，其中4篇论文出自护士 4项大会旅行资助